Genetics is a foundational discipline central to biomedical research and clinical practice. Our mission is to train geneticists for the 21st century. To achieve this goal, we have designed and implemented an interdisciplinary training program to transform graduate education in genetics and genomics at the University of Minnesota. Our NIH-funded predoctoral program aims to: (i) provide students with rigorous and quantitative training in the fundamentals and state- of-the-art advances in genetics, genomics, and computational biology; (ii) leverage the many collaborative research and educational strengths of our institution to provide new interdisciplinary student-centered graduate training opportunities that transcend departmental and collegiate boundaries; and (iii) generate a diverse cohort of well-trained scientists able to integrate their broad skillset and their hunger for lifelong learning into their work across a multitude of careers in the biomedical workforce. This program will enable trainees to pursue many impactful career opportunities in academia, biotechnology, government, health care, or education created by recent advancements in genetics and genomics, including careers in fields that are undergoing rapid change, as well as careers in areas that do not presently exist or that are nascent. Our training program includes 50 highly productive and collaborative faculty from ten departments across five colleges at the University of Minnesota. In addition to their thesis research, trainees participate in professional development programs aimed at promoting their transition into and long-term success in biomedical science-related careers.